Community Newsletter: Aggregations, Autism and ADHD Interference, and Calcium Signals | Domain

Illustration of scientists looking at a strand of DNA.

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How do the hundreds of genes linked to autism shape certain stages of human brain development? Sergio Pascaprofessor of psychiatry and behavioral sciences at Stanford University in California, tweeted a link to his new site Prepresswhere he and his colleagues used a “bold approach… to Map 425 genes in the interneuron’ development stages to answer this question.

Pasca and colleagues combined a previously developed stem cell-based platform with the CRISPR assay, revealing a surprising contribution from the endoplasmic reticulum, an organelle responsible for protein and lipid synthesis.

Maple La research fellow at Stanford University, described it as “a fascinating screen that revealed an unexpected role for Endoplasmic reticulum dynamics. “

Ambreen Fatimaan assistant professor at the Aga Khan University in Karachi, Pakistan, described the research as “a monumental work on The role of the NDD genes in the brain using assemblies”.

“This work is important in understanding Pathophysiology of human diseases, which will eventually help in the development of targeted therapies! Tweet on KCNC1 Foundationa non-profit organization in Toronto, Canada.

Cedric Boyksa research professor at the Catalan Institute for Research and Advanced Studies in Barcelona, ​​Spain, described the research as “a monumental work… that exploits the power of [brain] #organoids (aggregations) to highlight the role of interneuron development in Neurodevelopmental disorders. “

Another genetic study came to our attention Manuel Matissen, assistant professor of psychiatry at Dalhousie University in Halifax, Nova Scotia, Canada. He and colleagues found that individuals with autism and ADHD carry a double burden genetic risk for both disorders.

The Prepress It offers “new insights into the biological basis for developing only one or both disorders and for leading psychopathology discriminatively toward ADHD or ASD.”

Vera Rajagopal, a scientist at biotech company Regeneron Pharmaceuticals in Tarrytown, New York, tweeted that the analysis was “another fascinating and important work from the iPSYCH group on co- and differential relationships.” genetic architecture of ADHD and ASD. “

“Interested in participating Differentiate genetics Between Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder? ” chirp Pro Cormand RivaD., professor of genetics at the University of Barcelona in Spain and study investigator. “Check out our new primer!”

finally, Georgia Panagiotakua Sandler Fellow in Biochemistry and Biophysics at the University of California, San Francisco (UCSF), tweeted a link to her reconsidering “Describing how to draw calcium neurodevelopmental events in the crust.

“A great read for all who are interested brain development! ” chirp Tom Novakowskia developmental neurobiologist at UCSF.

“It looks so cool transmembrane proteins Got stuck! ” chirp wolf willow mystasa subsidiary of James FraserIn the UCSF laboratory.

Dan O’Sheaa neuroscientist and engineer at Stanford University, offered the congratulations, tweeting, “These charts do not believe.

That’s it in this week’s community newsletter! If you have any suggestions for interesting social posts you’ve seen in the field of autism research, feel free to send an email to [email protected].

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